Archives 2014

ISPOR, 17th Annual European Congress, Amsterdam, 8-12 November 2014

Stefan had two posters and  presented at a Short Course Afternoon Session on Sunday.

Four-hours Short Course:

“Applying Mixed Methods to Establish Content Validity of PRO, ClinRO, and ObsRO Assessments.”   
Burke LB, Patrick DL, Hobart JC, Cano SJ. International Society for Pharmacoeconomics and Outcomes Research, Amsterdam, Netherlands.

Poster Presentations:

THE PAIN ASSESSMENT FOR LOWER BACK SYMPTOMS (PAL-S): REFINEMENT OF A NEW PRO INSTRUMENT THROUGH A MIXED METHODS APPROACH.  McCarrier KP, Bushnell DM, Ramasamy A, Liedgens H, Blum SI, Cano S, Martin ML, Patrick DL. International Society for Pharmacoeconomics and Outcomes Research, Amsterdam, Netherlands (November, 2014).

IMPACTS OF LOWER BACK PAIN: REFINEMENT OF THE PAIN ASSESSMENT FOR LOWER BACK-IMPACTS QUESTIONNAIRE (PAL-I) USING A MIXED METHODS APPROACH. Bushnell DM, McCarrier KP, Ramasamy A, Liedgens H, Blum SI, Cano S, Martin ML, Patrick DL. . International Society for Pharmacoeconomics and Outcomes Research, Amsterdam, Netherlands (November, 2014).


Autumn Meeting of the British Society of Rhinoplasty Surgeons, Leicester, UK

Stefan was invited to participate as a speaker in the plenary about Outcome measurement in Rhinoplasty: The Prominence & Potential of Patient Reported Outcomes.


ISOQOL (20th Annual Conference of the International Society for Quality of Life Research, Berlin, Germany):

Stefan participated in a plenary session and an oral presentation.

  • Plenary session : 
    Expert Panel Discussion on Patient-Centered Outcome Measurement: Routes, Roadblocks, and Roadmaps (Thursday 16th October)

The Expert Panel Discussion focused on the current state of play of patient-centered outcome measurement from the perspective of the three speakers.

We first described the significant progress that has been made during our working careers, and then flagged some concerning problems in the field, in particular, the ‘routes’ (i.e. competing methodologies) and ‘roadblocks’ (i.e., barriers preventing widespread take up of state of the art techniques).

As exemplars we introduced five key challenges:
1) which measurement paradigm to guide instrument development and evaluation?
2) how to recognize the limitations of psychometric “statistics”?
3) how best to measure change over time?
4) what sample sizes for scale development and evaluation studies?
5) how to overcome the legacy of ‘legacy’ instruments?

We then described how the current best practice recommendations from the US Food and Drug Administration (the ‘Roadmap’) enable the development of clinically meaningful patient focused outcome measures.

Laurie Burke, MPH, LORA Group, LLC, United States
Jeremy C. Hobart, PhD FRCP, Clinical Neurology Research, Plymouth Univ. Peninsula Schools of Medicine and Dentistry, United Kingdom
Stefan J Cano, PhD, Modus Outcomes, Newton, MA, United States

  •  Oral Presentation

How Qualitative Methods Can Be Used to Ensure Content Validity in a PRO Instrument for Patients with Cleft Lip and/or Palate who Vary by Age and Culture?: Development of the CLEFT-Q.
Tsangaris E, Wong KWY, Forrest CR, Pusic A, Cano SJ, Goodacre T, Klassen AF20th Annual Conference of the International Society for Quality of Life Research, Berlin, Germ


Brookings/FDA Workshop, Washintgton DC, October 6,  2014

Patrick was invited to the Brookings/FDA workshop “Advancing Development and Use of Patient-Reported Outcomes in Drug Development: Near-Term Opportunities”. This meeting was a follow-up from a previous workshop that took place on July 16, which focused on experiences with the FDA’s guidance on PROs, as well as on challenges in capturing the patient voice across the drug development continuum.

This time, sessions focused on:
– I.   Developing a Potentially Acceptable Endpoint List: Potential Value and Uses – Implementation Approaches
– II.  Identifying Emerging Themes from the Acceptable Endpoints Discussion
– III. Evidentiary Considerations for Making Existing PRO Instruments Fit for Purpose
– IV. Identifying and Prioritizing Next Steps


Intense publication work by Stefan:

A new article in press:
Using Classical Test Theory, Item Response Theory, and Rasch Measurement Theory to Evaluate Patient-Reported Outcome (PRO) Measures: A Comparison of Worked Examples. Value in Health. Petrillo J, Cano SJ, McLeod L, Coon C (in press).

Just published IN FULL:
Assessing outcomes in body contouring. Klassen AF, Cano SJ, Scott A, Tsangaris E, Pusic AL. Clinics in Plastic Surgery 2014; 41(4): 645-654.
Staying at work and living with MS: a qualitative study of the impact of a vocational rehabilitation intervention. Jellie B, Sweetland J, Riazi A, Cano SJ, Playford ED. Disabil Rehabil. 2014 Disabil Rehabil. 2014;36(19):1594-9.

Two more publications about FACE-Q due to be presented at the American Society of Plastic Surgeons Annual Meeting: Read more about them!


Brookings/FDA Workshop, Washintgton DC, July16, 2014

Patrick was invited to the Brookings/FDA workshop “Enhancing the Development and Use of Patient-Reported Outcomes in Drug Development”, where the experience with FDA Guidance on PROs was discussed.

Sessions focused on:
– 1. Evidentiary Standards
– 2. Standardizing Communication Processes
– 3. Challenges to Capturing the Patient Voice Across the Drug Development
– 4. Next Steps in Promoting the Development and qualification of PROs


Three new publications in press for Stefan:

Lending a hand: Can DASH items help ABILHAND improve manual ability measurement in multiple sclerosis?
Barrett L, Cano SJ, Zajicek J, Hobart JC. Multiple Sclerosis Journal (in press)

Development and Validation of a Generic Scale for use in Transition Programs to Measure Self-Management Skills in Adolescents with Chronic Health Conditions: The TRANSITION-Q. Child: Care, Health & Development.
Klassen AF,Grant C, Barr R, Brill H, Olaf, K, Ronen G, Samaan C, Cano SJ, Torek, A, Athale U, Wickert N, Gorter JW (in press)

Introducing the BODY-Q: A Patient-Reported Outcome Instrument for use in Obesity, Bariatric and Body Contouring Surgery.
Klassen AF, Cano SJ, Scott A, Tsangaris E, Pusic AL. Clinics in Plastic Surgery (in press)


Summer publications by Stefan:

The development of scales to measure childhood cancer survivors’ readiness for transition to long-term follow-up care as adults.
Klassen AF, Rosenberg-Yunger ZR, D’Agostino NM, Cano SJ, Barr R, Syed I, Granek L, Greenberg ML, Dix D, Nathan PC. Journal: Health Expectations.
E-Published: July 2014

Viewpoint: Interpreting clinical differences in BREAST-Q© scores – Minimal Important Difference.
Cano SJ, Klassen AF, Scott A, Alderman A, Pusic A. Plastic and Reconstructive Surgery 134(1) 173-175

Stefan was also interviewed by the Times newspaper in the UK: “Tweets, Selfies and Surgery Trends by Antonia Mariconda” (15th July 2014)


Other recent publications:

Implant Breast Reconstruction and Radiation: a Multicenter Analysis of Long-Term Health-Related Quality of Life and Satisfaction.
Albornoz CR1, Matros E, McCarthy CM, Klassen AF, Cano SJ, Alderman AK, VanLaeken N, Lennox P, Macadam SA, Disa JJ, Mehrara BJ, Cordeiro PG, Pusic AL.
Ann Surg Oncol. 2014 Jul;21(7):2159-64. doi: 10.1245/s10434-014-3483-2. Epub 2014 Apr 18.

Towards Evidence-Based Practice in Cosmetic Surgery Using the Q-Portfolio of Patient-Reported Outcome Measures
Schwitzer J, Klassen AF, Cano SJ, Pusic AL.  Aesthetic Journal;  1(7) 2014. For more information:

Keep checking on Stefan’s academic outputs:


FACE London, June 20 to 22, 2014

Stefan gave two lectures at FACE on introducing the FACE-Q:  How Patient-Reported Outcome Measures (PROMs) can benefit clinical care.

Stefan is a Chartered Psychologist and co-developer (with Drs Anne Klassen (McMaster University, Canada) and Andrea Pusic (Memorial Sloan Kettering Cancer Center, USA)) of the BREAST-Q, FACE-Q, BODY-Q and CLEFT-Q. These PROMs quantify what patients think of the outcome (e.g., appearance, quality of life, adverse effects) following cosmetic and reconstructive treatment/surgery.

Introducing the FACE-Q:
In the aesthetics industry, patients are becoming savvy consumers. They want to know what other patients have experienced in order to make informed choices about treatments and to decide which clinician to use for optimal results. Such information gathered using the FACE-Q can be used to benefit clinical care. The FACE-Q was developed following current best practice guidelines for instrument development to satisfy the stringent requirements of governing and regulatory bodies. The FACE-Q is used internationally in clinical trials and research. It is also designed to be used by individual clinicians and technicians in their cosmetic practice to enable them to collect data from patients about expectations, satisfaction, outcomes and experience of care. For example, using the FACE-Q, a clinician may find that his or her patients considered their treatment outcomes to be excellent, but that they did not like his/her manner or were not satisfied with the office staff. Rather than lose dissatisfied patients to other providers, the clinician using the FACE-Q will better understand their patients’ concerns. Such accurate information helps to deliver higher quality care.


ISPOR Montreal, June 1 to 4, 2014

Both Stefan and Patrick participated as faculty or speaker in ISPOR sessions focused on good COAs measurement practices and methods.

– Sunday June1: Short Course Program in Patient-Reported Outcomes Methods
Applied Mixed Methods to establish content validity of Patient -Reported ( PRO), Clinician- Reported (ClinRo) and Observer-Reported Outcome (ObsRo) Assessments.
Faculty: Donald Patrick, MSPH, PhD; Laurie Burke, RPh, MPH; Jeremy Hobart, PhD, FRCP; Stefan J. Cano, PhD

– Monday June 2: Ispor Forums – Session 1: Ispor Clinician Reported Outcomes Good Measurement Practices
Moderator: John H. Powers, III, MD, FACP, FIDSA
Speakers: Laurie B. Burke; Patrick Marquis, MD, MBA; Ashley Slagle, PhD, MS


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